Early pharmacokinetic of ropivacaine without epinephrine after injection into the psoas compartment

Editor’s key points † This study investigated the early pharmacokinetics of ropivacaine without additional vasoconstrictor given as a psoas compartment block (PCB). † Ropivacaine plasma concentrations were detected within 30 s after injections. † Maximum measured plasma concentrations were measured within the first 10 min, but stayed below toxic threshold. † As some fraction of ropivacaine is systemically absorbed rapidly, caution is required and the use of a vasoconstrictor could be considered. Background. Large amounts of local anaesthetics (LA) are used during psoas compartment block (PCB), especially if combined with sciatic nerve block. Data regarding early pharmacokinetics of ropivacaine for PCB are lacking, notably when a vasoconstrictive agent has not been added.